By Peter Igaz
MicroRNAs because the endogenous mediators of RNA interference have skilled an exceptional profession in recent times, highlighting their pathogenic, diagnostic and capability healing relevance. Beside tissue microRNAs, also they are present in physique fluids, such a lot significantly in blood. major adjustments of circulating microRNA degrees were present in a variety of illnesses, making them applicants for minimally invasive markers of disorder, for instance tumor malignancy. The ebook focuses on the aptitude diagnostic applicability of circulating microRNAs in numerous ailments and their strength organic value.
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Additional info for Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance
32 33 35 35 37 39 40 40 42 43 43 44 47 48 Abstract Great excitement has surrounded the finding that small RNAs are stable in various biofluids and carry specific signatures reflecting physiological and pathological states. In this chapter, we briefly describe the impact of this revolutionary discovery and introduce different subclasses of circulating microRNAs based on their mode of transport. Subsequently, we review the current state-ofthe art knowledge on microRNA selection for export, secretion and possible uptake mechanisms and their potential function in circulation.
5 Predictive and Therapeutic Potential of Extracellular miRNAs . . . . . . . . . . . . . 1 Circulating miRNAs as Prospective Clinical Biomarkers . . . . . . . . . . . . 2 Therapeutic Potential of Extracellular miRNAs . . . . . . . . . . . . . . . . . 6 Conclusion and Future Perspectives of Circulating miRNAs . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . .
2009; Pegtel et al. 2010; Kosaka et al.
Circulating microRNAs in Disease Diagnostics and their Potential Biological Relevance by Peter Igaz