Well-liked clinicians and researchers from diversified disciplines talk about the elemental mobile and molecular biology of steroid motion and intercourse steroids' results at the worried and immune platforms. offers an built-in overview of the benefits and drawbacks of hormone alternative remedy.
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Additional info for Ciba Foundation Symposium 191 - Non-Reproductive Actions of Sex Steroids
There is some evidence, from Katzellenbogen and my colleagues Redeuilh and Sabba, that even in the absence of hormone there is some oestrogen receptor bound to DNA. Do you accept this? Beato: We cannot generalize: we haven’t done work on oestrogen. I don’t know whether anybody has looked carefully for genomic footprinting with oestrogen receptor and anti-oestrogens. 22 Discussion Parker: To date, only transfection experiments have been used to assess occupancy of a DNA binding site. This could be criticized on the basis of the copy number of DNA and the amount of receptor.
So whatever is in the membrane must be different from the intracellular receptor. Baufieu: The diversity of systems is such that it is very difficult to generalize the concept that part of the receptor activity occurs at the membrane level. From the literature and from our own experience I do not believe it. Muramatsu: As a membrane mechanism of steroid action, Matsuda et al (1993) found that oestrogen can bind to c-ErbB2 with very high affinityalmost as high affinity as the binding of oestrogen to oestrogen receptor.
Steroids may be integrated at interfaces between lipids and proteins, lying flat or on their edges according to their structural features (Munck 1957). The cholesterol content of cell membranes varies to some extent, and modulates their fluidity. It is conceivable that steroids could play a similar role (Willmer 1961). Pregnenolone, 17-hydroxypregnenolone and dehydroepiandrosterone (DHEA), which are precursors of hormonal A4-3-0x0-steroid hormones, are particularly suited for mimicking cholesterol, since they retain its 38-hydroxyA5 structure.
Ciba Foundation Symposium 191 - Non-Reproductive Actions of Sex Steroids