Download e-book for iPad: Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, by Susan C. Frost, Robert McKenna

By Susan C. Frost, Robert McKenna

ISBN-10: 9400773587

ISBN-13: 9789400773585

ISBN-10: 9400773595

ISBN-13: 9789400773592

The learn of carbonic anhydrase has spanned a number of generations of scientists. Carbonic anhydrase used to be first found in 1932 via Meldrum and Roughton. Inhibition by means of sulfanilamide used to be proven in 1940 through Mann and Keilin. Even Hans Krebs contributed to early experiences with a paper in 1948 displaying the connection of 25 assorted sulfonamides to CA inhibition. It was once he who mentioned the significance of either the charged and uncharged personality of those compounds for physiological experiments. the sector of analysis that makes a speciality of carbonic anhydrase (CA) has exploded in recent times with the id of latest households and isoforms. The CAs are metalloenzymes that are made from five structurally assorted households: the alpha, beta, gamma, and delta, and epsilon periods. The alpha category is located essentially in animals with numerous isoforms linked to human affliction. The beta CAs are expressed basically in vegetation and are the main divergent. The gamma CAs are the main old. those are structurally relating to the beta CAs, yet have a mechanism extra just like the alpha CAs. The delta CAs are present in marine algae and diflagellates. The epsilon classification is located in prokaryotes during which it's a part of the carboxysome shell probably offering RuBisCO with CO2 for carbon fixation. With the thrill surrounding the invention of disease-related CAs, scientists have redoubled their efforts to higher comprehend structure-function relationships, to layout excessive affinity, isotype-specific inhibitors, and to delineate signaling structures that play regulatory roles over expression and job. we've designed the ebook to hide simple info of mechanism, constitution, and serve as of the CA households. The authors incorporated during this ebook deliver to mild the latest facts in regards to the function of CA in body structure and pathology, throughout phylums, and in detailed environmental niches.

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Kaseda M, Ichihara N, Nishita T, Amasaki H, Asari M (2006) Immunohistochemistry of the bovine secretory carbonic anhydrase isozyme (CA-VI) in bovine alimentary canal and major salivary glands. J Vet Med Sci 68:131–135 121. Smith CE, Nanci A, Moffatt P (2006) Evidence by signal peptide trap technology for the expression of carbonic anhydrase 6 in rat incisor enamel organs. Eur J Oral Sci 114(Suppl 1):147–153 122. Kivela J, Parkkila S, Waheed A, Parkkila AK, Sly WS, Rajaniemi H (1997) Secretory carbonic anhydrase isoenzyme (CA VI) in human serum.

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Vullo D, Innocenti A, Nishimori I, Pastorek J, Scozzafava A, Pastorekova S, Supuran CT (2005) Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XII with sulfonamides – a new target for the design of antitumor and antiglaucoma drugs. Bioorg Med Chem Lett 15:963–969 180. Parkkila S, Parkkila AK, Saarnio J, Kivela J, Karttunen TJ, Kaunisto K, Waheed A, Sly WS, Tureci O, Virtanen I, Rajaniemi H (2000) Expression of the membrane-associated carbonic anhydrase isozyme XII in the human kidney and renal tumors.

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Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications by Susan C. Frost, Robert McKenna


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