By Golder Wilson
This extraordinary attempt prep consultant enables you to try your wisdom of crucial biochemistry and genetics thoughts for the USMLE Step 1; perform with 500 USMLE Step 1-style questions with referenced solutions; overview factors for correct and incorrect solutions; and construct self assurance, abilities, and information.
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Extra resources for Biochemistry and Genetics, 2007, p.514
Vigorous activity, hypermetabolic states (AIDS, cancer), and protein catabolism after trauma or inflammatory illnesses can increase the BMR up to eightfold (with skiing, stair climbing, jogging); intake of calories above those needed to maintain the BMR causes obesity, defined by a body mass index (weight in kilograms divided by height in meters squared) over 25–30. , the fragile/ misshapen bones of rickets) or more general phenotypes such as marasmus (muscle and tissue wasting, resigned affect), kwashiorkor (reddish hair, swollen liver, subcutaneous swelling = edema), and cachexia (exaggerated symptoms of marasmus with greater protein deficiency) from eating disorders (anorexia nervosa), chronic diseases (AIDS, lupus), or cancers.
Complex lipids include links to phosphoric acid (phospholipids), the 18-carbon aminoalcohol sphingosine (sphingophospholipids), carbohydrate (glycosphingolipids), and proteins (including lipoproteins). • Derived lipids include saturated (no double bonds) or polyunsaturated fatty acids (multiple double bonds), polyunsaturated fatty acids with rings (eicosanoids including prostaglandins and leukotrienes, vitamins including E and K), steroids derived from cholesterol including hormones (aldosterone, estrogen, testosterone) or vitamins (vitamin D), and polymers containing ceramide (a sphingosine derivative), carbohydrates (generating cerebrosides), or carbohydrates with sialic acid (gangliosides).
Vitamin deficiency diseases are listed in Table 7 along with scientific uses of high-dose vitamin therapy (to overcome altered enzyme/cofactor binding in specific genetic disorders or to lower risks for birth defects). , zinc, iron, copper). HORMONES AND INTEGRATED METABOLISM Key concepts:Types of hormones and hormone action (Murray, pp 434-473. ) • Integrated actions of the endocrine and neural systems produce hormones, acting on distant cells (endocrine), adjacent cells (paracine), or the same cell (autocrine) as agonists (stimulants) or antagonists (inhibitors) of various cell functions.
Biochemistry and Genetics, 2007, p.514 by Golder Wilson