New PDF release: Basic Principles in Nucleic Acid Chemistry. Volume 2

By Paul O. P. Ts'o

ISBN-10: 0127019014

ISBN-13: 9780127019017

ISBN-10: 0127019022

ISBN-13: 9780127019024

Show description

Read Online or Download Basic Principles in Nucleic Acid Chemistry. Volume 2 PDF

Best general & reference books

Peptides: Chemistry and Biology - download pdf or read online

Peptides play a decisive position in lots of physiological approaches, even if as neurotransmitters, hormones or antibiotics. The fast advancements in peptide learn during the last few a long time make it virtually most unlikely for novices to achieve an summary. this implies an simply understandable but concise creation is key.

Get Organic Chemistry I Workbook For Dummies PDF

From types to molecules to mass spectrometry-solve natural chemistry issues of ease acquired a clutch at the natural chemistry phrases and ideas you must be aware of, yet wander off midway via an issue or worse but, now not comprehend the place to start? haven't any worry - this hands-on advisor is helping you resolve the numerous varieties of natural chemistry difficulties you come upon in a targeted, step by step demeanour.

Download e-book for kindle: Topics in Stereochemistry, Volume 19 by Ernest L. Eliel, Samuel H. Wilen, Norman L. Allinger

This sequence is meant for the complicated scholar, the instructor and the energetic researcher and historical past for the fundamental wisdom within the box of stereochemistry is thought. every one bankruptcy is written via knowledgeable within the box and covers its topic extensive. The authors have selected themes of basic import aimed essentially at an viewers of natural chemists yet concerned usually with primary rules of actual chemistry and molecular physics, and working additionally with sure stereochemical points of inorganic chemistry and biochemistry.

Additional resources for Basic Principles in Nucleic Acid Chemistry. Volume 2

Sample text

Many studies of subcritical heating have been made [352]. The process in DNA is considered to depend on loss of purine bases, guanine rather faster than adenine, and as a consequence, chain scission. Both can be measured [352355]. In circular single-stranded X174 DNA the rate of depurination and of inactivation are similar and are considered to be distinguishable from the subsequent scission step [356,357]. Poly dAT undergoes slow chain scission (~pH 4) which is associated with loss of adenine and appearance of terminal 3/-phosphate residues [358].

Dicarbonyl Compounds The antiviral activity of ß-ethoxy-a-ketobutyraldehyde (Kethoxal) (108) inspired the investigation [153] of its action and that of glyoxal and of related compounds on the nucleic acid bases. Of the compounds studied 1. Reactions of Polynucleotides and Nucleic Acids 27 those that inactivated tobacco mosaic virus RNA also reacted rapidly with guanine, but not with the other base residues. These α-dicarbonyl compounds, therefore, show a satisfying degree of specificity. With Kethoxal a product could also be obtained from 7V2-methylguanine and from isocytosine but not from 1-methylguanine, indicating that the 1- and N 2 -positions were in­ volved in the reaction.

NBS has been used for selective bromination of yeast tRNA Ala [231], while bromine itself has been used with tRNA in DMF solution [229], and with poly C [232]. Iodination is not nearly so readily effected. Iodine in potassium iodide solution is ineffective at 37°C. IC1 in DMF, has been investigated and the order of reactivity U > C » G found [228]. JV-Iodosuccinimide is rapidly destroyed by water but it does iodinate uracil and cytosine residues in TMV-RNA, the latter more rapidly [226]. A recently investigated system is iodide in presence of the oxidizing agent thallic trichloride in water.

Download PDF sample

Basic Principles in Nucleic Acid Chemistry. Volume 2 by Paul O. P. Ts'o


by James
4.5

Rated 4.52 of 5 – based on 27 votes