Download e-book for iPad: Ataxia - A Medical Dictionary, Bibliography, and Annotated by Icon Health Publications

By Icon Health Publications

ISBN-10: 0597843406

ISBN-13: 9780597843402

ISBN-10: 1417512601

ISBN-13: 9781417512607

It is a 3-in-1 reference publication. It supplies a whole scientific dictionary masking enormous quantities of phrases and expressions on the subject of ataxia. It additionally offers vast lists of bibliographic citations. eventually, it offers details to clients on tips to replace their wisdom utilizing a variety of net assets. The ebook is designed for physicians, clinical scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to get to grips with examine devoted to ataxia. in case your time is efficacious, this publication is for you. First, you won't waste time looking out the web whereas lacking loads of suitable details. moment, the publication additionally saves you time indexing and defining entries. eventually, you won't waste money and time printing 1000s of web content.

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Additional info for Ataxia - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

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However, more knowledge of both the cellular factors that influence cerebellar development, and optimal methods for altering these will be required, The long-term goal of this project is to establish methods to manipulate the cerebellum genetically. This will require both knowledge of the hierarchy of gene expression, and a capacity to deliver and control gene therapies. Experiments in this proposal will encompass both the underlying developmental neurobiology and vector technology to manipulate the genes.

The long term goals of these studies are to 1) understand the molecular targets of mitochondrial oxidative stress both at the genetic and protein level within the brain, & 2) characterize the efficacy of synthetic antioxidants in preventing many of the CNS disorders which present due to mitochondrial oxidative stress within the brain. The specific aims are 1) Characterize the metabolism of the affected areas of the brain to determine if there is a metabolic differential relative to unaffected areas; 2) Determine whether cell loss contributes to the progression of the spongiform changes; 3) Characterize at the biochemical and enzymatic level the changes due to mitochondrial oxidative stress within the brain and the efficacy of various synthetic antioxidants in attenuating such changes; 4) Investigate gene expression changes in the brain in relation to endogenous mitochondrial oxidative stress via microarray analysis.

Professor; Genetics, Cell Biology & Develpmnt; University of Minnesota Twin Cities 200 Oak Street Se Minneapolis, Mn 554552070 Timing: Fiscal Year 2002; Project Start 16-JUN-2000; Project End 31-MAY-2005 Summary: (adapted from applicant's abstract): The investigator recently cloned a CTG expansion that causes a novel form of spinocerebellar ataxia (SCA8) and demonstrated that the repeat is transcribed in the CTG-orientation, as in myotonic dystrophy, but not the CAG-orientation, as reported for all of the other SCAs.

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Ataxia - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Icon Health Publications


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